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Paclitaxel analogs modified in ring C: Synthesis and biological evaluation

โœ Scribed by Xian Liang; David G.I. Kingston; Byron H. Long; Craig A. Fairchild; Kathy A. Johnston

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
1017 KB
Volume
53
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesulfonyl-7-epi-paclitaxel derivative with DMAP yields a 20-O-acetyl-4-deacetyl-5,6-dehydro-6-formyI-C-nor-paclitaxel derivative. C-nor-paclitaxel analogs ~e less active than paclitaxel.

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