Synthesis and biological activity of a novel C4–C6 bridged paclitaxel analog
✍ Scribed by Haiqing Yuan; David G.I. Kingston; Dan L. Sackett; Ernest Hamel
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 676 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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AbstractÐStructure modi®cation of paclitaxel at the C-6 and C-7 positions has been achieved using the readily available intermediate 6ahydroxy-7-epipaclitaxel (2). While a single diastereomer of the cyclic sul®te of 2 was prepared at lower temperature, both diastereomers were obtained at room temper
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