Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesu
Synthesis and biological evaluation of paclitaxel analogs modified in ring C
โ Scribed by Xian Liang; David G.I. Kingston; Chii M. Lin; Ernest Hamel
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 240 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
AbstractรStructure modiยฎcation of paclitaxel at the C-6 and C-7 positions has been achieved using the readily available intermediate 6ahydroxy-7-epipaclitaxel (2). While a single diastereomer of the cyclic sulยฎte of 2 was prepared at lower temperature, both diastereomers were obtained at room temper
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.