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Total synthesis and biological evaluation of marinopyrrole A and analogs

✍ Scribed by K.C. Nicolaou; Nicholas L. Simmons; Jason S. Chen; Nina M. Haste; Victor Nizet

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
305 KB
Volume
52
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

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