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Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

✍ Scribed by Arun K. Ghosh; Zachary L. Dawson; Deuk Kyu Moon; Ruoli Bai; Ernest Hamel

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
393 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.

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