✦ LIBER ✦

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

✍ Scribed by Leslie N. Aldrich; Sydney L. Stoops; Brenda C. Crews; Lawrence J. Marnett; Craig W. Lindsley

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 718 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.154

No coin nor oath required. For personal study only.

✦ Synopsis

Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.

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