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The new “one-flask” synthesis of 14C labelled 1-bromoalkanes - synthesis of 1-bromo [1-14c] heptane

✍ Scribed by Tomáš Elbert; Jiří Filip

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
407 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Conditions were found for almost quantitative carboxylation of n-hexyllithium with l4CO2 to afford lithium [1-l4C] heptanoate.

It was then possible to perform the reaction sequence lithium [1-l4C] heptanoate --+ [l-14C] heptan-1-01 + 1-bromo [l-14q heptane in one flask without isolation of intermediates. In the "hot" synthesis 12,8 GBq (346 mCi) of 1-bromo [l-14CJ heptane with radiochemical purity better than 97 % were prepared from Bal4CO3 in 81 % yield.

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