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The Contribution of BRCA1 and BRCA2 to Ovarian Cancer

✍ Scribed by Susan J. Ramus; Simon A. Gayther


Book ID
119328870
Publisher
Wiley (John Wiley & Sons)
Year
2009
Tongue
English
Weight
492 KB
Volume
3
Category
Article
ISSN
1574-7891

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Contribution of BRCA1 and BRCA2 mutation
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A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (