A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (
The Contribution of Germline BRCA1 and BRCA2 Mutations to Familial Ovarian Cancer: No Evidence for Other Ovarian Cancer–Susceptibility Genes
✍ Scribed by Simon A. Gayther; Paul Russell; Patricia Harrington; Antonis C. Antoniou; Douglas F. Easton; Bruce A.J. Ponder
- Book ID
- 117853005
- Publisher
- American Society of Human Genetics
- Year
- 1999
- Tongue
- English
- Weight
- 435 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/302583
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