In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population
โ Scribed by Song, H.; Cicek, M. S.; Dicks, E.; Harrington, P.; Ramus, S. J.; Cunningham, J. M.; Fridley, B. L.; Tyrer, J. P.; Alsop, J.; Jimenez-Linan, M.; Gayther, S. A.; Goode, E. L.; Pharoah, P. D. P.
- Book ID
- 121790056
- Publisher
- Oxford University Press
- Year
- 2014
- Tongue
- English
- Weight
- 110 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0964-6906
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Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population
The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo