A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (
Contribution of BRCA1 and BRCA2 Mutations to Breast and Ovarian Cancer in Pakistan
โ Scribed by Alexander Liede; Imtiaz A. Malik; Zeba Aziz; Patricia de los Rios; Elaine Kwan; Steven A. Narod
- Book ID
- 117853998
- Publisher
- American Society of Human Genetics
- Year
- 2002
- Tongue
- English
- Weight
- 182 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/342506
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Among Asian countries, Pakistan has the highest rates of breast and ovarian cancer. To assess the contribution of the __BRCA1__ and __BRCA2__ germ line mutations to these high rates, we conducted the first study of 176 Pakistani breast and ovarian cancer patients, selected on family his
We report on the screening of the entire BRCA1/BRCA2 coding sequence by SSCP, PTT, and direct sequencing in 68 Italian families with recurrent breast or ovarian cancer. For each investigated proband, the probability of being carrier of a BRCA1/BRCA2 mutation was evaluated using the BRCAPRO software.