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Contribution of BRCA1 and BRCA2 to Familial Ovarian Cancer: A Gynecologic Oncology Group Study

✍ Scribed by Mark Reedy; Holly Gallion; Jeffrey M. Fowler; Richard Kryscio; Simon A. Smith


Book ID
112248890
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
49 KB
Volume
85
Category
Article
ISSN
0090-8258

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A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (