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The association between hypoxia inducible factor-1α gene polymorphisms and increased susceptibility to oral cancer

✍ Scribed by Mu-Kuan Chen; Hui-Ling Chiou; Shih-Chi Su; Tsung-Te Chung; Hsien-Chun Tseng; Hsiu-Ting Tsai; Shun-Fa Yang

Book ID
113833238
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
157 KB
Volume
45
Category
Article
ISSN
1368-8375

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## Abstract The hypoxia inducible factor‐1α (HIF‐1α) has been found to be involved in several different physiological mechanisms, such as blood‐vessel formation, apoptosis, and erythropoiesis. HIF‐1α is hydroxylated at normoxia and rapidly degraded via the von Hippel–Lindau (VHL)/ubiquitin‐proteaso