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Association of hypoxia inducible factor-1α polymorphisms with susceptibility to non–small-cell lung cancer

✍ Scribed by Wu-Hsien Kuo; Chuen-Ming Shih; Chiao-Wen Lin; Wei-Erh Cheng; Shuo-Chueh Chen; Wei Chen; Yao-Ling Lee

Book ID
118501706
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
270 KB
Volume
159
Category
Article
ISSN
1931-5244

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## Abstract Hypoxia‐inducible factor (HIF)‐1α is the regulatory subunit of HIF‐1 that is stabilized under hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF‐1α as a prognostic factor. This study