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Hypoxia-inducible factor-1α polymorphisms are associated with genetic aberrations in lung cancer

✍ Scribed by ANDIKA C. PUTRA; KEIJI TANIMOTO; MARINA ARIFIN; KEIKO HIYAMA


Book ID
108965547
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
364 KB
Volume
16
Category
Article
ISSN
1323-7799

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## Abstract The hypoxia inducible factor‐1α (HIF‐1α) has been found to be involved in several different physiological mechanisms, such as blood‐vessel formation, apoptosis, and erythropoiesis. HIF‐1α is hydroxylated at normoxia and rapidly degraded via the von Hippel–Lindau (VHL)/ubiquitin‐proteaso