No association of the hypoxia-inducible factor-1α gene polymorphisms with survival in patients with colorectal cancer
✍ Scribed by Soo Jung Lee; Jong Gwang Kim; Sang Kyun Sohn; Yee Soo Chae; Joon Ho Moon; Byung Woog Kang; Jun Seok Park; Jin Young Park; Gyu Seog Choi
- Book ID
- 107577234
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 286 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1357-0560
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## Abstract The hypoxia inducible factor‐1α (HIF‐1α) has been found to be involved in several different physiological mechanisms, such as blood‐vessel formation, apoptosis, and erythropoiesis. HIF‐1α is hydroxylated at normoxia and rapidly degraded via the von Hippel–Lindau (VHL)/ubiquitin‐proteaso
## Abstract With an incidence of about 300 000 new cases colorectal cancer (CRC) is the second leading cause of cancer‐related death in Europe and the United States. Environmental and genetic factors influence CRC risk. Hypoxia‐inducible factor‐1 (HIF‐1), a heterodimeric protein composed of two sub