𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Association between ulcerative growth and hypoxia inducible factor-1α polymorphisms in colorectal cancer patients

✍ Scribed by Karin Fransén; Matthew Fenech; Mats Fredrikson; Charlotta Dabrosin; Peter Söderkvist

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
208 KB
Volume
45
Category
Article
ISSN
0899-1987

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The hypoxia inducible factor‐1α (HIF‐1α) has been found to be involved in several different physiological mechanisms, such as blood‐vessel formation, apoptosis, and erythropoiesis. HIF‐1α is hydroxylated at normoxia and rapidly degraded via the von Hippel–Lindau (VHL)/ubiquitin‐proteasome degradation system to prevent angiogenesis. In a previous study, the C1772T (P582S) and the G1790A (A588T) polymorphisms were identified in the human HIF‐1α gene, which was shown to have a higher transactivating capability in vitro compared to the wild type allele. However, the role for these polymorphisms in vivo is still unclear. In the present investigation, we have therefore studied the role of the two polymorphic variants in the development of colorectal cancer (CRC) with PCR/RFLP (restriction fragment length polymorphism), single strand conformation analysis (SSCA), and immunohistochemistry (IHC). A significant higher‐risk was identified between patients heterozygous for the C1772T polymorphism and the more severe ulcerative growth pattern compared to homozygous C1772C wild type tumors (RR = 5.2; 95% CI 1.26–21.6; P = 0.006). This was also verified on the allelic level (RR = 6.5; 95% CI 1.58–26.8; P = 0.001). In addition, patients carrying one or more polymorphic alleles in either the HIF‐1α C1772T or the G1790A polymorphisms display significant higher risk for the development of ulcerative CRCs (RR = 4.17; 95% CI = 1.33–13.08; P = 0.004). These results suggest that the HIF‐1α polymorpisms are an important factor for development of a subset of ulcerative intestinal tumors. Future screening of the polymorphic HIF‐1α allele may therefore be of importance in the selection of treatment strategies of CRC. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Single nucleotide polymorphisms in the h
Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk
✍ Gudrun Knechtel; Joanna Szkandera; Michael Stotz; Günter Hofmann; Uwe Langsenleh 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 1 views

## Abstract With an incidence of about 300 000 new cases colorectal cancer (CRC) is the second leading cause of cancer‐related death in Europe and the United States. Environmental and genetic factors influence CRC risk. Hypoxia‐inducible factor‐1 (HIF‐1), a heterodimeric protein composed of two sub

Hypoxia-inducible factor-1α in non small
Hypoxia-inducible factor-1α in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
✍ Daniel E.B. Swinson; J. Louise Jones; Giles Cox; Donna Richardson; Adrian L. Har 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

## Abstract Hypoxia‐inducible factor (HIF)‐1α is the regulatory subunit of HIF‐1 that is stabilized under hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF‐1α as a prognostic factor. This study

Thrombin induces expression of twist and
Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells
✍ Li-Hsun Chang; Chun-Han Chen; Der-Yi Huang; Hui-Chen Pai; Shiow-Lin Pan; Che-Min 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract Deep vein thrombosis associated with advanced cancer is known as Trousseau's syndrome. We hypothesized that thrombin, an activator of protease‐activated receptor (PAR)‐1 and PAR‐4 contributes to tumor metastasis. In this study, we demonstrated that thrombin and the PAR‐1 activating pept

Association of hypoxia-inducible factors
Association of hypoxia-inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
✍ Efthimios Sivridis; Alexandra Giatromanolaki; Kevin C. Gatter; Adrian L. Harris; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 417 KB 👁 1 views

## Background: Hypoxia-inducible factor 1alpha (hif-1alpha) and hif-2alpha are essential regulatory proteins for the adaptation of tumor cells to hypoxia, and they stimulate angiogenesis through activation of the vascular endothelial growth factor (vegf) gene. ## Methods: Hif-1alpha and hif-2alph

Overexpression of hypoxia-inducible fact
Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
✍ Jean-Philippe Dales; Stéphane Garcia; Séverine Meunier-Carpentier; Lucile Andrac 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 372 KB

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that is involved in tumour growth and metastasis by regulating genes involved in response to hypoxia. HIF-1alpha protein overexpression has been shown in a variety of human cancers, but only 2 studies have documented the prognost