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Association between the polymorphisms in exon 12 of hypoxia-inducible factor-1α and the clinicopathological features of oral squamous cell carcinoma

✍ Scribed by Tzong-Ming Shieh; Kuo-Wei Chang; Hsi-Feng Tu; Yin-Hua Shih; Shun-Yao Ko; Yuan-Chien Chen; Chung-Ji Liu

Book ID
113833366
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
608 KB
Volume
46
Category
Article
ISSN
1368-8375

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## Abstract The transcription factor hypoxia‐inducible factor‐1α (HIF‐1α) is the key regulator that controls the hypoxic response of mammalian cells. The overexpression of HIF‐1α has been demonstrated in many human tumors. However, the role of HIF‐1α in the therapeutic efficacy of chemotherapy and