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The Antibody Catalysis Route to the Total Synthesis of Epothilones

โœ Scribed by Subhash C. Sinha, Carlos F. Barbas and Richard A. Lerner


Book ID
123641686
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
937 KB
Volume
95
Category
Article
ISSN
0027-8424

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๐Ÿ“œ SIMILAR VOLUMES


The Formal Total Synthesis of Epothilone
โœ Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartm ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 347 KB ๐Ÿ‘ 2 views

The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio