𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The Formal Total Synthesis of Epothilone A

✍ Scribed by Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartmut H. Meyer

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
347 KB
Volume
1999
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reaction efficient route to keto acid 5 is described. (RCM) and the diastereoselective alkylation at C8. Aldehyde

πŸ“œ SIMILAR VOLUMES

Total Synthesis of (βˆ’)-Epothilone A
Total Synthesis of (βˆ’)-Epothilone A
✍ Dieter Schinzer; Armin Bauer; Oliver M. BΓΆhm; Anja Limberg; Martin Cordes πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 200 KB πŸ‘ 2 views
Total Synthesis of (–)-Epothilone A
Total Synthesis of (–)-Epothilone A
✍ Dr. Aaron Balog; Dongfang Meng; Dr. Ted Kamenecka; Dr. Peter Bertinato; Dr. Dai- πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 360 KB πŸ‘ 1 views
Total Synthesis of (βˆ’)-Epothilone A
Total Synthesis of (βˆ’)-Epothilone A
✍ Prof. Dr. Dieter Schinzer; Dipl.-Chem. Anja Limberg; Dipl.-Chem. Armin Bauer; Di πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 231 KB πŸ‘ 1 views

3117. !L = 10.11 cm-I. crystal dimensions 0.3 x 0 3x0.4mm. Mo,, radiation (0.71073 A). measurement at 150(2) K. Final R (on F) and wR2 (on F2) were 0 030 and 0 090. respectively, for all 11 760 unique data. Final G O F = 0.95. and the final difference fourier map showed no peak at greater than + 0.8

A Formal Total Synthesis of (+)-Pinnatox
A Formal Total Synthesis of (+)-Pinnatoxin A
✍ Satoshi Sakamoto; Hayato Sakazaki; Koji Hagiwara; Kei Kamada; Kento Ishii; Takes πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 362 KB
A Formal Total Synthesis of (+)-Pinnatox
A Formal Total Synthesis of (+)-Pinnatoxin A
✍ Satoshi Sakamoto; Hayato Sakazaki; Koji Hagiwara; Kei Kamada; Kento Ishii; Takes πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 361 KB