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Total Synthesis of (–)-Epothilone A

✍ Scribed by Dr. Aaron Balog; Dongfang Meng; Dr. Ted Kamenecka; Dr. Peter Bertinato; Dr. Dai-Shi Su; Dr. Erik J. Sorensen; Prof. Samuel J. Danishefsky

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
360 KB
Volume
35
Category
Article
ISSN
0044-8249

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Total Synthesis of (−)-Epothilone A
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Total Synthesis of (−)-Epothilone A
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✍ Prof. Dr. Dieter Schinzer; Dipl.-Chem. Anja Limberg; Dipl.-Chem. Armin Bauer; Di 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB

3117. !L = 10.11 cm-I. crystal dimensions 0.3 x 0 3x0.4mm. Mo,, radiation (0.71073 A). measurement at 150(2) K. Final R (on F) and wR2 (on F2) were 0 030 and 0 090. respectively, for all 11 760 unique data. Final G O F = 0.95. and the final difference fourier map showed no peak at greater than + 0.8

The Formal Total Synthesis of Epothilone
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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio