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Total Synthesis of (−)-Epothilone A

✍ Scribed by Dieter Schinzer; Armin Bauer; Oliver M. Böhm; Anja Limberg; Martin Cordes

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
200 KB
Volume
5
Category
Article
ISSN
0947-6539

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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio