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A Formal Total Synthesis of (+)-Pinnatoxin A

✍ Scribed by Satoshi Sakamoto; Hayato Sakazaki; Koji Hagiwara; Kei Kamada; Kento Ishii; Takeshi Noda; Masayuki Inoue; Masahiro Hirama


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
362 KB
Volume
43
Category
Article
ISSN
0044-8249

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Total Synthesis of Pinnatoxin A
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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio

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## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygen‐mediated palladium‐catalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.