A Formal Total Synthesis of (+)-Pinnatoxin A
β Scribed by Satoshi Sakamoto; Hayato Sakazaki; Koji Hagiwara; Kei Kamada; Kento Ishii; Takeshi Noda; Masayuki Inoue; Masahiro Hirama
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 361 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0044-8249
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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio
## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygenβmediated palladiumβcatalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.