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A Formal Total Synthesis of Palmerolide A

✍ Scribed by Parthasarathy Gowrisankar; Sandip A. Pujari; Krishna P. Kaliappan


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
258 KB
Volume
16
Category
Article
ISSN
0947-6539

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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio