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ChemInform Abstract: The Epothilones: Total Synthesis of Epothilones A—F

✍ Scribed by Johann Mulzer; Kathrin Prantz


Publisher
John Wiley and Sons
Year
2009
Weight
15 KB
Volume
40
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
✍ D. SCHINZER; A. LIMBERG; A. BAUER; O. M. BOEHM; M. CORDES 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou