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ChemInform Abstract: Total Synthesis of (-)-Epothilone A.

โœ Scribed by D. SCHINZER; A. LIMBERG; A. BAUER; O. M. BOEHM; M. CORDES

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneous completely functionalized fragment (VI), which in a key ring-closure metathesis step yields (VII). This highly convergent synthetic sequence can be easily extended to analogues that are very important in view of their biological activity.

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ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of Epothilone A: The Olefin Metathesis Approach.
โœ Z. YANG; Y. HE; D. VOURLOUMIS; H. VALLBERG; K. C. NICOLAOU ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 1 views

Total Synthesis of Epothilone A: The Olefin Metathesis Approach. -Starting with the three building blocks (I)-(III) the coupling product (IV) is obtained. It is used for olefin metathesis as the key step in the synthesis of the title compound (VI). -(YANG, Z.;