Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou
โฆ LIBER โฆ
ChemInform Abstract: Total Synthesis of Epothilone A.
โ Scribed by Rama M. Hindupur; Bijoy Panicker; Muralikrishna Valluri; Mitchell A. Avery
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 23 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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Total Synthesis of Epothilone A: The Olefin Metathesis Approach. -Starting with the three building blocks (I)-(III) the coupling product (IV) is obtained. It is used for olefin metathesis as the key step in the synthesis of the title compound (VI). -(YANG, Z.;
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