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ChemInform Abstract: Total Synthesis of Epothilone A: The Olefin Metathesis Approach.

✍ Scribed by Z. YANG; Y. HE; D. VOURLOUMIS; H. VALLBERG; K. C. NICOLAOU

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Total Synthesis of Epothilone A: The Olefin Metathesis Approach. -Starting with the three building blocks (I)-(III) the coupling product (IV) is obtained. It is used for olefin metathesis as the key step in the synthesis of the title compound (VI). -(YANG, Z.;

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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou