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ChemInform Abstract: Catalytic Antibody Route to the Naturally Occurring Epothilones: Total Synthesis of Epothilones A—F.

✍ Scribed by Subhash C. Sinha; Jian Sun; Gregory P. Miller; Markus Wartmann; Richard A. Lerner

Publisher: John Wiley and Sons
Year: 2010
Weight: 28 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200209244

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Total Synthesis of Epothilone A: The Olefin Metathesis Approach. -Starting with the three building blocks (I)-(III) the coupling product (IV) is obtained. It is used for olefin metathesis as the key step in the synthesis of the title compound (VI). -(YANG, Z.;