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ChemInform Abstract: The Formal Total Synthesis of Epothilone A.

โœ Scribed by Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartmut H. Meyer

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
31
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES

The Formal Total Synthesis of Epothilone
The Formal Total Synthesis of Epothilone A
โœ Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartm ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 347 KB ๐Ÿ‘ 2 views

The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio

ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of (-)-Epothilone A.
โœ D. SCHINZER; A. LIMBERG; A. BAUER; O. M. BOEHM; M. CORDES ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 1 views

Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou