T cell regulation of collagen-induced arthritis in mice. II. Immunomodulation of arthritis by cytotoxic T cell hybridomas specific for type II collagen
✍ Scribed by Gilles Chiocchia; Marie-Christophe Boissier; Bénédicte Manoury; Catherine Fouriner
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 598 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^
## Objective: To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (cia). ## Methods: T cell receptor beta transgenic (tcrbetal) mice that have a t cell repertoire that predisposes to the development of cia were used. classic genetic studies