Genetic control of susceptibility to collagen-induced arthritis in T cell receptor β-chain transgenic mice

✍ Scribed by Lucia Mori; Gennaro de Libero

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 692 KB
• Volume: 41
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/1529-0131(199802)41:2<256::aid-art9>3.0.co;2-e

✦ Synopsis

Objective:

To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (cia).

Methods:

T cell receptor beta transgenic (tcrbetal) mice that have a t cell repertoire that predisposes to the development of cia were used. classic genetic studies and microsatellite gene mapping were done in (swr-betal x dba/1)f2 hybrid mice.

Results:

Besides tcrbeta, major histocompatibility complex class ii, and igh-c, at least 2 other genes are absolutely required for cia development in these mice. a strict association of cia with the presence of functional complement c5 allele (hc1) was found, suggesting that hc1 or a closely linked gene might be one of these essential genes.

Conclusion:

This study provides new evidence of the pathogenetic role of complement c5 in cia. furthermore, these transgenic mice may facilitate molecular identification of other genes that predispose to cia.