Resistance to collagen-induced arthritis in Biozzi mice is not associated with T cell receptor Vβ gene polymorphism
✍ Scribed by Laurent Vidard; Thierry Roger; Jean Pierre Bouvet; Jacques Couderc; Michel Seman
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 328 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
H‐I and H‐II high antibody‐responder Biozzi mice, which express the H‐2^q^ permissive haplotype, were shown to be sensitive and refractory to collagen‐induced arthritis, respectively. To assess a possible role of T cell receptor (TcR) V~β~ gene deletion or polymorphism in the resistance to arthritis in H‐II mice, the germinal structure of TcR V~β~ genes and their expression at the membrane level were compared in both lines. In contrast to H‐2^q^ refractory SWR mice, which exhibit a deletion of about 50% of TcR V~β~ gene segments, H‐I and H‐II lines have an identical and complete set of V~β~ genes and exhibit no difference in the average expression of V~β~6, V~β~8 and V~β~11 gene products on T cell surface. These results indicate that mechanisms other than V~β~ gene deletion or polymorphism can be involved in the resistance of H‐2^q^‐positive mice to experimental arthritis.