Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis
✍ Scribed by Johan Bäcklund; Alexandra Treschow; Robert Bockermann; Björn Holm; Lotta Holm; Shohreh Issazadeh-Navikas; Jan Kihlberg; Rikard Holmdahl
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 174 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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📜 SIMILAR VOLUMES
## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^
## Abstract ## Objective Type II collagen (CII) is a candidate autoantigen implicated in the pathogenesis of rheumatoid arthritis (RA). Posttranslational glycosylation of CII could alter intracellular antigen processing, leading to the development of autoimmune T cell responses. To address this po