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Anti-T cell receptor antibody treatment of rats with established autologous collagen-induced arthritis: suppression of arthritis without reduction of anti-type II collagen autoantibody levels

✍ Scribed by Tom J. Goldschmidt; Rikard Holmdahl

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 441 KB
Volume: 21
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830210536

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## Abstract ## Objective To test the effects of a novel monoclonal antibody (mAb) against human osteopontin (OPN) in the prevention and treatment of collagen‐induced arthritis (CIA) and to elucidate the underlying mechanisms of these effects. ## Methods DBA/1J mice immunized with type II collage