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Synthesis of specifically tritium-labelled oxytocin and lysine-vasopressin with high specific activity

✍ Scribed by Ingvar Sjöholm; Lars Carlsson

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
663 KB
Volume
3
Category
Article
ISSN
0022-2135

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✦ Synopsis

Highly tritium-iabelled oxy tocin and lysine-vasopressin have been synthesized. L-tyrosine-3-3H was prepared from L-3-iodotyrosine and tritium gas in methanolic potassium hydroxide with palladium on active carbon as a catalyst. The tritiated oxytocin and lysinevasopressin were obtained from the tritiated tyrosine and the heptapeptides of oxytocin and lysine-vasopressin, respectively, by the p-nitrophenyl ester method. The peptides had a high degree of purity and the specijic radioactivity was 2.9 Clmmole or 5.9 pC/IU for oxjtocin and 1.9 Clmmole or 6.5 pClIU for lysine-vasopressin. The high radioactivity of the peptides permits extensive studies of their properties in vivo. The stability of the tritium label is discussed.

* A preliminary report has already been published ( 8 ) .

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