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Synthesis of N-[11C]-methyl-L-DOPA

✍ Scribed by Dr. Andrew Horti; Hayden T. Ravert; Robert F. Dannals; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
409 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The radiochemical synthesis of N‐[^11^C‐methyl]‐L‐DOPA was accomplished by N‐methylation of the methyl and ethyl esters of L‐N‐tert‐butyl‐oxycarbonyl‐[β‐(3,4‐dimethoxyphenyl)] alaninate with [^11^C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N‐methyl intermediate with hydriodic acid. A catalytic influence of Kryptofix on the methylation reaction was observed. Using the ethyl ester precursor, the average specific activity at the end‐of‐synthesis was 972 mCi/μmole. The synthesis was completed in an average of 45 minutes following the end‐of‐bombardment.

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