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Synthesis of [N-methyl-11C]mianserin: a tetracyclic, atypical antidepressant

✍ Scribed by K. Marthi; D. Bender; D.F. Smith

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
216 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

As part of our program to develop PET tracers for investigating monoaminergic processes in the brain, mianserin, a tetracyclic, atypical antidepressant, was selected as a candidate for labelling with ^11^C for in vivo evaluation. [N‐methyl‐^11^C]Mianserin was produced by the alkylation of N‐desmethyl mianserin with [^11^C]methyl iodide followed by HPLC purification and formulation. [N‐methyl‐^11^C]Mianserin was obtained with a radiochemical purity >93% in a 16% decay corrected radiochemical yield. For a typical production starting with 40 GBq [^11^C]CO~2~, 1.9 GBq [N‐methyl‐^11^C]mianserin was obtained as a formulated solution in a synthesis time of 35 min (counted from EOB). Copyright © 2001 John Wiley & Sons, Ltd.

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