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A convenient synthesis of [11C]paraquat and other [N-methyl-11C]bisquaternary ammonium compounds

✍ Scribed by Douglas M. Jewett; Michael R. Kilbourn

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
100 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^11^C]Paraquat was synthesized by the reaction of [^11^C]methyl triflate with the mono‐triflate salt of 1‐methyl‐[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method was applied to the synthesis of a variety of [N‐methyl‐^11^C]bisquaternary ammonium compounds. This is the first reported use of a chelating cation exchange resin for the selective purification of organic dications. Copyright © 2002 John Wiley & Sons, Ltd.

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