W e describe here t h e synthesis of twoC1lC-methylJlabelled analogs of choline and the influence of t h e solvent, addition of a base, and reaction t i m e on t h e radiochemical yield. The reactions produced equally good yields in methanol and acetonitrile and r e a f p d maximum radiochemical yi
Synthesis of non - carrier added [N - methyl - 11C] roxithromycine
✍ Scribed by L. Barre; M. C. Lasne; P. Charbonneau
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 130 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Roxithromycine, a new macrolide, was labelled with [^11^C]CH~3~I in a good radiochemical yield (40‐45%)and high specific activities (500‐550mCi/μmol). This antibiotic may be useful for detecting pulmonar or cerebral infection foci using positron emission tomography.
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