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Synthesis of D/L- and L-SE-[methyl-11C]selenomethionine

✍ Scribed by Kjell Någren; Bengt Långström

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
207 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

11 The syntheses o f D/L-and L-Se-[methyl-Clselenomethionine a r e reported. The Se-benzyl selenohomocyst e i n e s were deprotected i n s o d i u m / l i q u i d ammonia and t h e selenide anions generated i n s i t u were a l k y l a t e d w i t h C Clmethyl i o d i d e t o g i v e , a f t e r p u r i f i c a t i o n by LC, t h e products i n 80 t o 85 % radiochemical y i e l d , w i t h a radiochemical p u r i t y h i g h e r than 99 % w i t h i n 30 rnin and w i t h a s p e c i f i c r a d i o a c t i v i t y o f 20 t o 200 mCi/pmol. The enantiomeric p u r i t y o f t h e L-compound, determined by LC, was h i g h e r than 99 $.

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