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New method for routine production of L-[methyl-11C]methionine: in loop synthesis

✍ Scribed by Vanessa Gómez; Juan Domingo Gispert; Víctor Amador; Jordi Llop

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
124 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A fast, clean and reproducible method for the manufacture of the radiotracer L‐[methyl‐^11^C]methionine is reported. The reaction at room temperature of the non‐radioactive precursor L‐homocysteine (1 mg solution in ethanol/water 50/50) with [^11^C]CH~3~I in an HPLC loop led to the formation of the desired radiotracer with a high radiochemical yield (38.4±4.1% end of synthesis) in a short production time (12 min). Radiochemical purity of the final radiotracer was 99.9±0.05%. Specific activities in the range 11–45 GBq/µmol were obtained. The presence of the undesired enantiomer (D‐[methyl‐^11^C]methionine) was not detected in any of the cases. Copyright © 2008 John Wiley & Sons, Ltd.

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