✦ LIBER ✦
Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)
✍ Scribed by Robert F. Dannals; John L. Neumeyer; Richard A. Milius; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner Jr.
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 320 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐^11^C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [^11^C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.