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Synthesis, chromatography and tissue distribution of methyl-11c-morphine and methyl-11C-heroin

✍ Scribed by G. Kloster; H.-J. Machulla; E. Röder

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
260 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

C-Morphine was prepared by methylation of normorphine with CH31. Acetylation of this compound yields heroin. The radiochemical yield is 9% for morphine and 4 % for heroin at a specific activity of 1.63 mCi/pmole. Synthesis time including purification by hplc is 18 min for "C-morphine and 36 min for llC-heroin, respectively. The tissue distribution of both these compounds was determined in rats at different times after an i.v. injection.

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