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Synthesis, chromatography and tissue distribution of 1-[11 C]-hexobarbital

✍ Scribed by G. Kloster; C. Müller-Platz

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
274 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐[^11^C]‐Hexobarbital was synthetized by methylation of norhexobarbital using ^11^CH~3~I. The maximum radiochemical yield after purification by hplc is 47% at a specific activity of 1.0 mCi/μmole. Synthesis time including purification is 37 min. The tissue distribution was determined in mice at different times after i.v. injection. The main accumulation of activity during the first hour after i.v. injection is in liver and kidneys. Other well perfused organs like brain, heart and lung show significant accumulation only during the first minutes after injection.

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