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[11C]Labeling of coenzyme Q10 and its tissue distribution

✍ Scribed by T. Takahashi; T. Ido; R. Iwata; K. Ishiwata; K. Hamamura; K. Kogure

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
334 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Medicine, 4 -1 Seiryo-cho, Sendai, 9 8 0 , Japan SUMMARY 11 [ CICoenzyme Q10 was synthesized by 0-methylation of 3demethyl coenzyme Ql0 with 11CH31. We have produced 1-4 mCi of [ Clcoenzyme Q10 with radiochemical yields of 6-16 % (based on trapping "CH I) in 35-50 min with radiochemical purities of > 9 5 %. The specific activity was 4 -5 mCi/pmol at the end of [ C ]coenzyme Q10 synthesis. The tissue distribution was investigated on mongolian gerbils after intravenous administration of [ "C]coenzyme Q10 solubilized with polyoxyethylene hydrogenated caster oil (HCO-60). The blood level of [llC]coenzyme Q10 was very high and its clearance was slow.

The accumulations in the heart, kidney and liver were moderate and the accumulation in the brain was low in spite of its high lipophilicity.

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