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Synthesis of L-[5-11C]ornithine

✍ Scribed by Yu-Shin Ding; Gunnar Antoni; Joanna S. Fowler; Alfred P. Wolf; Bengt Langstrom

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
474 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

No-carrier-added L-[5-11C]ornithine was synthesized in 25-40% radiochemical yield in a synthesis time of 50 min (EOB) and a specific ac vity >2.1 Ci/umol by the displacement reaction of potassium ['fC]cyanide with the functionally protected y- bromohomoserine followed by selective reduction of the [ llC]nitrile with cobalt chloride-sodium borohydride complex, deprotection with 6M HCl(,q), and purification by HPLC. studies It was found that cyanide ion is generated from acetonitrile in the presence of potassium hydroxide and kryptofix 222.

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