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Ornithine decarboxylase activity in tumor: A study with L-[1–14C]- and L-[5–14C]-ornithine

✍ Scribed by Ph.H. Elsinga; B.J.G. Daemen; W. Vaalburg

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
114 KB
Volume
26
Category
Article
ISSN
0022-2135

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✦ Synopsis

The aim of this study is to investigate the possibility to measure ornithine decarboxylase (ODC) activity by PET. From the metabolic pathways of L-ornithine (fig. 1) can be concluded that the difference in uptake of L-[l-l4C]-ornithine (L-1-orn) and L-[5-14C]-ornithine (L-5-orn) may reflect the ODC-activity, assuming that 14C02 is cleared from the tissue rapidly. Decarboxylation of L-ornithine forming putrescine is the initial and rate limiting step to polyamine biosynthesis (1).

Polyamine levels and ODC-activity are increased in many rapid growing tissues like tumors (2). D,L-1-orn is applied in animals and patients to measure the decarboxylation by ODC both in vitro and in vivo (3). D,L-[1-11CI-ornithine is shown to accumulate in tumors (4), while D,L-5-orn is used as a marker of polyamine levels in tissues.

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