No-carrier-added L-[5-11C]ornithine was synthesized in 25-40% radiochemical yield in a synthesis time of 50 min (EOB) and a specific ac vity >2.1 Ci/umol by the displacement reaction of potassium ['fC]cyanide with the functionally protected y- bromohomoserine followed by selective reduction of the [
A versatile synthesis of C-5 labeled ornithines
โ Scribed by John Wityak; Venkatapuram A. Palaniswamy; Steven J. Gould
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 367 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
I4C-Labeled inosine 5'-phosphate was synthesized by direct phosphorylation of i n 0 s i n e -8 -~~C with phosphoryl chloride followed by hydrolysis of the resulting phosphorodichloridate. Isolation and recrystallization o f its disodium salt afforded pure material in 66.8% overall chemical yield.
## Abstract For Abstract see ChemInform Abstract in Full Text.
The aim of this study is to investigate the possibility to measure ornithine decarboxylase (ODC) activity by PET. From the metabolic pathways of L-ornithine (fig. 1) can be concluded that the difference in uptake of L-[l-l4C]-ornithine (L-1-orn) and L-[5-14C]-ornithine (L-5-orn) may reflect the ODC-